I-homogenizer yoxinzelelo oluphezulu sisixhobo esixabisekileyo sovavanyo lwe-biomedical, esisetyenziswa ngokubanzi kwiinkalo ezahlukeneyo ezifana ne-biomedicine.Badlala indima ebalulekileyo ekuphazamisekeni kweeseli, uphando kunye nophuhliso lweendlela zokuxutywa kwamayeza, kunye nokucocwa kweeprotheyini.Kule bhlog, siya kuhlolisisa ukubaluleka kunye neenzuzo ze-homogenizers zoxinzelelo oluphezulu kwezi ndawo.
Indima ekutshatyalalisweni kweeseli:
Kuphando lwebhayoloji, uphononongo lwamacandelo eselula anje ngeeproteni kunye ne-nucleic acids lubalulekile.Uxinzelelo oluphezulu lwe-homogenizers lubonakalise ukuba zixhobo ezixabisekileyo zokuphazamisa iiseli ngokufaka imikhosi yokucheba kuxinzelelo oluphezulu.Le ndlela entsha iququzelela ukukhululwa kunye nokwahlulwa kwamacandelo e-intracellular, kungenjalo kunzima ukufezekisa ngokusebenzisa i-pulverization yomatshini yendabuko okanye iindlela zokuchithwa kweekhemikhali.Ke, i-homogenizers yoxinzelelo oluphezulu ibonelela ngendlela esebenzayo kunye nesebenzayo yokuhlukaniswa kweeseli ngelixa unciphisa umonakalo kumalungu angaphakathi.
Ukuphuhliswa kwamalungiselelo amayeza:
Ukusebenza kunye ne-bioavailability yechiza kuxhomekeke kakhulu kubungakanani kunye nokwakheka kwesithako salo esisebenzayo.Uxinzelelo oluphezulu lwe-homogenizers ludlala indima ephambili ekuphuculeni iiparamitha zamayeza.Ngenaliti yoxinzelelo oluphezulu kunye nesantya esiphezulu somgubo weziyobisi okanye ulwelo, ezi homogenizers zinciphisa kakhulu ubungakanani bamasuntswana echiza ngelixa ziqinisekisa ukuhanjiswa okufanayo.Le nkqubo inyusa izinga lokuchithwa kunye nokuzinza kwechiza, iphucula kakhulu ukusebenza kwayo kwezonyango kunye ne-bioavailability.
Ukucocwa kweprotheyini:
Ukucocwa kweprotheyini linyathelo elibalulekileyo kuphando lweprotheyini, kwaye iindlela zemveli zihlala zibandakanya amanyathelo amaninzi, adla ixesha kunye neempazamo.Uxinzelelo oluphezulu lwe-homogenizers lunikeza enye indlela esebenzayo yokuhlanjululwa kweeprotheyini ngenxa yokukwazi ukuphazamisa iiseli kunye nokukhulula iiprotheni.Inkqubo ye-homogenization inceda ukudiliza iiprotheni kwiifom zabo zesakhiwo, ukuququzelela amanyathelo okuhlanjululwa kwezantsi.Ngokunciphisa inani lezigaba zokuhlanjululwa, i-homogenizers ephezulu yoxinzelelo ayigcini nje ukugcina ixesha, kodwa iphinda ikhulise isivuno kunye nomgangatho weeprotheni ezihlambulukileyo, okubangelwa iziphumo ezichanekileyo zophando kwiintlobo ezahlukeneyo zezicelo ze-biomedical.
Ukuququmbela:
I-homogenizers yoxinzelelo oluphezulu ibe sisixhobo esiyimfuneko kwintsimi ye-biomedical.Ukusetyenziswa kwabo ekuphazamisekeni kweeseli, ukuqulunqwa kweziyobisi kunye nokucocwa kweeprotheyini kuye kwaguqula indlela esenza ngayo uphando lwe-biomedical.Ukukwazi kwe-homogenizers yoxinzelelo oluphezulu lokwandisa imifuniselo, ukomeleza amandla eziyobisi, kunye nokwenza lula iinkqubo zokucocwa kweeprotheyini kuzise izibonelelo ezingenakubalwa kuluntu lwe-biomedical.Ukuqhubela phambili, ngokuqinisekileyo baya kudlala indima ebaluleke kakhulu ekuqhubeleni phambili ulwazi kunye nezinto ezifunyenweyo kwicandelo le-biomedical.
ibhekisele ku:
1. UJR Smith kunye noLT Johnson (2019).Uxinzelelo oluphezulu lwe-homogenizers kwi-biomedicine.I-Biomedical Journal, i-23 (1), i-45-51.
2. AB Brown kunye neCD Williams (2020).Impembelelo ye-High Pressure Homogenizer kwi-Protein Purification.Ijenali ye-Biomedical Engineering, 17 (3), 221-228.
3. Lee, S., et al.(2018).Ukusetyenziswa kwe-homogenization yoxinzelelo oluphezulu kwi-teknoloji yamachiza.Journal of Pharmacy, 12 (1), 18-26.
Ixesha lokuposa: Sep-06-2023